Yes Lacerator or Atma's Scarab can be your friend. But there are PI's in the game whose immunity can't be broken so it's a good idea to have some elemental damage weapon at hand like Gimmershred. You can shop magical or gamble rare throwing axes with good elemental damage. Add in a poison charm or Open Wounds modifier to prevent the PI's regen and you're good to go.
Venture to the Realms Beyond to get off the beaten path.