-choose too many incompatible skills
-choose too many incompatible runes
-wear the wrong gear
-use skills in combat the wrong way
you shouldn't run out of resources? You should still be able to do something? Are we supposed to die at all in this game? I mean, yeah, OOM was pretty annoying, and more of a gear check than anything tactical (especially in D2). But if there are no penalties for misusing your resources, then why even have them in the first place? Unless you flip the paradigm and go the fighting game route; you can do almost everything w/o any resources, but the big stuff, the super combos, the combo breakers, etc, cost resources. Don't think that'd work too well in the isometric environment, though.
Earth or somewhere like it.